MARCH1 FISH Probe
The MARCH1 FISH probe is designed to hybridize to the MARCH1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MARCH1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-RE | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-GO | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-GR | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-AQ | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-DIG | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Gene Details
Gene Symbol: MARCH1
Gene Name: Membrane Associated Ring-CH-type Finger 1
Chromosome: CHR4: 164445449-165304407
Locus: 4q32.2-q32.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MARCH1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MARCH1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping