MAP3K4 FISH Probe
The MAP3K4 FISH probe is designed to hybridize to the MAP3K4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP3K4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MAP3K4-20-RE | 20 (40 μL) | 200 μL |  |
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| MAP3K4-20-GO | 20 (40 μL) | 200 μL |  |
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| MAP3K4-20-GR | 20 (40 μL) | 200 μL |  |
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| MAP3K4-20-AQ | 20 (40 μL) | 200 μL |  |
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| MAP3K4-20-DIG | 20 (40 μL) | 200 μL |  |
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| MAP3K4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: MAP3K4
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 4
Chromosome: CHR6: 161412821-161538417
Locus: 6q26
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MAP3K4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MAP3K4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping