MAM-3 FISH Probe
The MAM-3 FISH probe is designed to hybridize to the MAM-3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAML2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MAML2-20-RE | 20 (40 μL) | 200 μL |  |
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| MAML2-20-GO | 20 (40 μL) | 200 μL |  |
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| MAML2-20-GR | 20 (40 μL) | 200 μL |  |
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| MAML2-20-AQ | 20 (40 μL) | 200 μL |  |
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| MAML2-20-DIG | 20 (40 μL) | 200 μL |  |
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| MAML2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Gene Details
Gene Symbol: MAML2
Gene Name: Mastermind Like Transcriptional Coactivator 2
Chromosome: CHR11: 95711439-96076344
Locus: 11q21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MAM-3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MAML2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping