LRP2 Break Apart FISH Probe
Empire Genomics’ LRP2 Break Apart FISH Probe is designed to flank the LRP2 gene and is typically used for detecting LRP2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP2BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP2BA-20-GORE | 20 (40 μL) | 200 μL |
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| LRP2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| LRP2BA-20-REGO | 20 (40 μL) | 200 μL |
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| LRP2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Gene Details
Gene Symbol: LRP2
Gene Name: LDL Receptor Related Protein 2
Chromosome: CHR2: 169983618-170219122
Locus: 2q31.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LRP2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LRP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping