LRP2 FISH Probe
The LRP2 FISH probe is designed to hybridize to the LRP2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LRP2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| LRP2-20-RE | 20 (40 μL) | 200 μL |  |
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| LRP2-20-GO | 20 (40 μL) | 200 μL |  |
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| LRP2-20-GR | 20 (40 μL) | 200 μL |  |
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| LRP2-20-AQ | 20 (40 μL) | 200 μL |  |
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| LRP2-20-DIG | 20 (40 μL) | 200 μL |  |
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| LRP2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Gene Details
Gene Symbol: LRP2
Gene Name: LDL Receptor Related Protein 2
Chromosome: CHR2: 169983618-170219122
Locus: 2q31.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LRP2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LRP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping