LPCAT1 FISH Probe
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LPCAT1 FISH Probe
The LPCAT1 FISH probe is designed to hybridize to the LPCAT1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe
is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes
hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping
This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]
Plasma membrane remodeling is a mechanism employed by cancer cells to increase nutrient uptake and intercellular signaling. In this study, researchers identified the LPCAT1 gene as a driver of membrane remodeling, finding that growth factor receptor-driven cancers rely heavily on the gene to reshape cell membranes through enhanced saturated phosphatidylcholine content. Genomic analysis of publicly available cancer sequencing databases of clinical samples and the cancer cell line encyclopedia (CCLE) revealed LPCAT1 amplification in over 30% of pan-cancer patients. This discovery was made possible by Empire Genomics’ LPCAT1 FISH probe, which was used to detect amplification of the gene.