LIG4 FISH Probe
The LIG4 FISH probe is designed to hybridize to the LIG4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LIG4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| LIG4-20-RE | 20 (40 μL) | 200 μL |  |
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| LIG4-20-GO | 20 (40 μL) | 200 μL |  |
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| LIG4-20-GR | 20 (40 μL) | 200 μL |  |
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| LIG4-20-AQ | 20 (40 μL) | 200 μL |  |
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| LIG4-20-DIG | 20 (40 μL) | 200 μL |  |
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| LIG4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: LIG4
Gene Name: DNA Ligase 4
Chromosome: CHR13: 108859791-108870716
Locus: 13q33.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LIG4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LIG4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping