LEFTY2 FISH Probe
The LEFTY2 FISH probe is designed to hybridize to the LEFTY2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LEFTY2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| LEFTY2-20-RE | 20 (40 μL) | 200 μL |  |
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| LEFTY2-20-GO | 20 (40 μL) | 200 μL |  |
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| LEFTY2-20-GR | 20 (40 μL) | 200 μL |  |
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| LEFTY2-20-AQ | 20 (40 μL) | 200 μL |  |
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| LEFTY2-20-DIG | 20 (40 μL) | 200 μL |  |
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| LEFTY2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Gene Details
Gene Symbol: LEFTY2
Gene Name: Left-right Determination Factor 2
Chromosome: CHR1: 226124297-226129083
Locus: 1q42.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LEFTY2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LEFTY2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping