LDS4 FISH Probe
The LDS4 FISH probe is designed to hybridize to the LDS4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TGFB2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TGFB2-20-RE | 20 (40 μL) | 200 μL |  |
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| TGFB2-20-GO | 20 (40 μL) | 200 μL |  |
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| TGFB2-20-GR | 20 (40 μL) | 200 μL |  |
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| TGFB2-20-AQ | 20 (40 μL) | 200 μL |  |
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| TGFB2-20-DIG | 20 (40 μL) | 200 μL |  |
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| TGFB2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Gene Details
Gene Symbol: TGFB2
Gene Name: Transforming Growth Factor Beta 2
Chromosome: CHR1: 218518675-218617961
Locus: 1q41
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LDS4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TGFB2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping