LDLR Break Apart FISH Probe
Empire Genomics’ LDLR Break Apart FISH Probe is designed to flank the LDLR gene and is typically used for detecting LDLR rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LDLRBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LDLRBA-20-AQOR | 20 (40 μL) | 200 μL |
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| LDLRBA-20-GOGR | 20 (40 μL) | 200 μL |
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| LDLRBA-20-GORE | 20 (40 μL) | 200 μL |
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| LDLRBA-20-GRGO | 20 (40 μL) | 200 μL |
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| LDLRBA-20-GROR | 20 (40 μL) | 200 μL |
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| LDLRBA-20-GRRE | 20 (40 μL) | 200 μL |
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| LDLRBA-20-REGO | 20 (40 μL) | 200 μL |
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| LDLRBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Gene Details
Gene Symbol: LDLR
Gene Name: Low Density Lipoprotein Receptor
Chromosome: CHR19: 11200037-11244505
Locus: 19p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LDLR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LDLR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping