LCR-OPSIN FISH Probe
The LCR-OPSIN FISH probe is designed to hybridize to the LCR-OPSIN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OPSIN-LCR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| OPSIN-LCR-20-RE | 20 (40 μL) | 200 μL |  |
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| OPSIN-LCR-20-GO | 20 (40 μL) | 200 μL |  |
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| OPSIN-LCR-20-GR | 20 (40 μL) | 200 μL |  |
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| OPSIN-LCR-20-AQ | 20 (40 μL) | 200 μL |  |
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| OPSIN-LCR-20-DIG | 20 (40 μL) | 200 μL |  |
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| OPSIN-LCR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This genomic region represents a locus control region (LCR) that controls cone cell-specific and mutually exclusive expression of the red and green cone pigment genes. These genes, which are present in an array on chromosome X, include one red pigment gene (opsin 1, long-wave-sensitive; OPN1LW) and one or more green pigment genes (opsin 1, medium-wave-sensitive; OPN1MW, OPN1MW2 and OPN1MW3 in the reference genome assembly). The LCR core region, which is located approximately 3.1-3.7 kb upstream of the OPN1LW gene, binds to transcription factors associated with retinal development, and it forms looping interactions with the cone pigment gene promoters. It is thought that mutually exclusive expression in individual cone cells is achieved by LCR interaction with only one gene promoter, and that genes in the cone pigment array may be preferentially selected based on distance from the LCR and/or local chromatin domain conformation. This LCR has been used to drive expression of heterologous genes in cone cells, and it has a potential use for gene therapy of achromatopsia and other retinal diseases. Mutations in this LCR result in X-linked blue cone monochromacy (BCM), and loss of the LCR results in a disrupted cone mosaic organization. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: OPSIN-LCR
Gene Name: Opsin Locus Control Region
Locus: Xq28
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: LCR-OPSIN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: OPSIN-LCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping