LATS1 Break Apart FISH Probe
Empire Genomics’ LATS1 Break Apart FISH Probe is designed to flank the LATS1 gene and is typically used for detecting LATS1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LATS1BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| LATS1BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Gene Details
Gene Symbol: LATS1
Gene Name: Large Tumor Suppressor Kinase 1
Chromosome: CHR6: 149982050-150039392
Locus: 6q25.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: LATS1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LATS1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping