KPNB1 FISH Probe
The KPNB1 FISH probe is designed to hybridize to the KPNB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KPNB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| KPNB1-20-RE | 20 (40 μL) | 200 μL |  |
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| KPNB1-20-GO | 20 (40 μL) | 200 μL |  |
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| KPNB1-20-GR | 20 (40 μL) | 200 μL |  |
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| KPNB1-20-AQ | 20 (40 μL) | 200 μL |  |
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| KPNB1-20-DIG | 20 (40 μL) | 200 μL |  |
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| KPNB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Details
Gene Symbol: KPNB1
Gene Name: Karyopherin Subunit Beta 1
Chromosome: CHR17: 45727274-45761004
Locus: 17q21.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KPNB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KPNB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping