KOS FISH Probe
The KOS FISH probe is designed to hybridize to the KOS gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UBE3B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| UBE3B-20-RE | 20 (40 μL) | 200 μL |  |
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| UBE3B-20-GO | 20 (40 μL) | 200 μL |  |
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| UBE3B-20-GR | 20 (40 μL) | 200 μL |  |
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| UBE3B-20-AQ | 20 (40 μL) | 200 μL |  |
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| UBE3B-20-DIG | 20 (40 μL) | 200 μL |  |
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| UBE3B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Gene Details
Gene Symbol: UBE3B
Gene Name: Ubiquitin Protein Ligase E3B
Chromosome: CHR12: 109915438-109974507
Locus: 12q24.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KOS FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: UBE3B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping