KNL1 Break Apart FISH Probe
Empire Genomics’ KNL1 Break Apart FISH Probe is designed to flank the KNL1 gene and is typically used for detecting KNL1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KNL1BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| KNL1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| KNL1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| KNL1BA-20-GORE | 20 (40 μL) | 200 μL |
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| KNL1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| KNL1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| KNL1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| KNL1BA-20-REGO | 20 (40 μL) | 200 μL |
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| KNL1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
Gene Details
Gene Symbol: KNL1
Gene Name: Kinetochore Scaffold 1
Chromosome: CHR15: 40594011-40664341
Locus: 15q15.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KNL1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KNL1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping