KLRK1 Break Apart FISH Probe
Empire Genomics’ KLRK1 Break Apart FISH Probe is designed to flank the KLRK1 gene and is typically used for detecting KLRK1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLRK1BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-GORE | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-REGO | 20 (40 μL) | 200 μL |
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| KLRK1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Gene Details
Gene Symbol: KLRK1
Gene Name: Killer Cell Lectin Like Receptor K1
Chromosome: CHR12: 10524951-10542653
Locus: 12p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KLRK1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KLRK1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping