KLR FISH Probe
The KLR FISH probe is designed to hybridize to the KLR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KLRK1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| KLRK1-20-RE | 20 (40 μL) | 200 μL |  |
|
| KLRK1-20-GO | 20 (40 μL) | 200 μL |  |
|
| KLRK1-20-GR | 20 (40 μL) | 200 μL |  |
|
| KLRK1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| KLRK1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| KLRK1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Gene Details
Gene Symbol: KLRK1
Gene Name: Killer Cell Lectin Like Receptor K1
Chromosome: CHR12: 10524951-10542653
Locus: 12p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: KLR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KLRK1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping