KIR-2DS4 FISH Probe
The KIR-2DS4 FISH probe is designed to hybridize to the KIR-2DS4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KIR2DS4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| KIR2DS4-20-RE | 20 (40 μL) | 200 μL |  |
|
| KIR2DS4-20-GO | 20 (40 μL) | 200 μL |  |
|
| KIR2DS4-20-GR | 20 (40 μL) | 200 μL |  |
|
| KIR2DS4-20-AQ | 20 (40 μL) | 200 μL |  |
|
| KIR2DS4-20-DIG | 20 (40 μL) | 200 μL |  |
|
| KIR2DS4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: KIR2DS4
Gene Name: Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4
Chromosome: CHR19: 55344173-55360023
Locus: 19q13.42
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: KIR-2DS4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KIR2DS4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping