KCNQ1OT1 FISH Probe
The KCNQ1OT1 FISH probe is designed to hybridize to the KCNQ1OT1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KCNQ1OT1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| KCNQ1OT1-20-RE | 20 (40 μL) | 200 μL |  |
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| KCNQ1OT1-20-GO | 20 (40 μL) | 200 μL |  |
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| KCNQ1OT1-20-GR | 20 (40 μL) | 200 μL |  |
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| KCNQ1OT1-20-AQ | 20 (40 μL) | 200 μL |  |
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| KCNQ1OT1-20-DIG | 20 (40 μL) | 200 μL |  |
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| KCNQ1OT1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Human chromosomal region 11p15.5 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The human CDKN1C/KCNQ1OT1 domain is regulated by an ICR located in an intron of KCNQ1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the KCNQ1OT1 gene that is exclusively expressed from the paternal allele. The KCNQ1OT1 transcript is the antisense to the KCNQ1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. The transcript is abnormally expressed from both chromosomes in most patients with Beckwith-Wiedemann syndrome, and the transcript also plays an important role in colorectal carcinogenesis. [provided by RefSeq, Apr 2012]
Gene Details
Gene Symbol: KCNQ1OT1
Gene Name: KCNQ1 Opposite Strand/antisense Transcript 1 (non-protein Coding)
Chromosome: CHR11: 2661767-2721228
Locus: 11p15.5
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KCNQ1OT1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KCNQ1OT1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping