JMML FISH Probe
The JMML FISH probe is designed to hybridize to the JMML gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTPN11-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PTPN11-20-RE | 20 (40 μL) | 200 μL |  |
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| PTPN11-20-GO | 20 (40 μL) | 200 μL |  |
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| PTPN11-20-GR | 20 (40 μL) | 200 μL |  |
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| PTPN11-20-AQ | 20 (40 μL) | 200 μL |  |
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| PTPN11-20-DIG | 20 (40 μL) | 200 μL |  |
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| PTPN11-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Gene Details
Gene Symbol: PTPN11
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 11
Chromosome: CHR12: 112856535-112947717
Locus: 12q24.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: JMML FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTPN11-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping