IWU1 FISH Probe
The IWU1 FISH probe is designed to hybridize to the IWU1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FXYD5-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FXYD5-20-RE | 20 (40 μL) | 200 μL |  |
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| FXYD5-20-GO | 20 (40 μL) | 200 μL |  |
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| FXYD5-20-GR | 20 (40 μL) | 200 μL |  |
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| FXYD5-20-AQ | 20 (40 μL) | 200 μL |  |
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| FXYD5-20-DIG | 20 (40 μL) | 200 μL |  |
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| FXYD5-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Gene Details
Gene Symbol: FXYD5
Gene Name: FXYD Domain Containing Ion Transport Regulator 5
Chromosome: CHR19: 35645624-35660788
Locus: 19q13.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IWU1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FXYD5-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping