The IREB2 FISH probe is designed to hybridize to the IREB2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
IREB2-20-OR  (Standard Design) 20 (40 μL) 200 μL
IREB2-20-RE 20 (40 μL) 200 μL
IREB2-20-GO 20 (40 μL) 200 μL
IREB2-20-GR 20 (40 μL) 200 μL
IREB2-20-AQ 20 (40 μL) 200 μL
IREB2-20-DIG 20 (40 μL) 200 μL
IREB2-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Gene Details

Gene Symbol: IREB2

Gene Name: Iron Responsive Element Binding Protein 2

Chromosome: CHR15: 78730517-78793798

Locus: 15q25.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: IREB2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL


Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping