IREB2 FISH Probe
The IREB2 FISH probe is designed to hybridize to the IREB2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IREB2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IREB2-20-RE | 20 (40 μL) | 200 μL |  |
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| IREB2-20-GO | 20 (40 μL) | 200 μL |  |
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| IREB2-20-GR | 20 (40 μL) | 200 μL |  |
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| IREB2-20-AQ | 20 (40 μL) | 200 μL |  |
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| IREB2-20-DIG | 20 (40 μL) | 200 μL |  |
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| IREB2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: IREB2
Gene Name: Iron Responsive Element Binding Protein 2
Chromosome: CHR15: 78730517-78793798
Locus: 15q25.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IREB2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IREB2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping