INSDEGM FISH Probe
The INSDEGM FISH probe is designed to hybridize to the INSDEGM gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IDE-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IDE-20-RE | 20 (40 μL) | 200 μL |  |
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| IDE-20-GO | 20 (40 μL) | 200 μL |  |
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| IDE-20-GR | 20 (40 μL) | 200 μL |  |
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| IDE-20-AQ | 20 (40 μL) | 200 μL |  |
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| IDE-20-DIG | 20 (40 μL) | 200 μL |  |
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| IDE-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Gene Details
Gene Symbol: IDE
Gene Name: Insulin Degrading Enzyme
Chromosome: CHR10: 94211440-94333852
Locus: 10q23.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: INSDEGM FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IDE-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping