IMD5 FISH Probe
The IMD5 FISH probe is designed to hybridize to the IMD5 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SH2D1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SH2D1A-20-RE | 20 (40 μL) | 200 μL |  |
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| SH2D1A-20-GO | 20 (40 μL) | 200 μL |  |
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| SH2D1A-20-GR | 20 (40 μL) | 200 μL |  |
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| SH2D1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| SH2D1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| SH2D1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: SH2D1A
Gene Name: SH2 Domain Containing 1A
Chromosome: CHRX: 123480131-123507010
Locus: Xq25
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IMD5 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SH2D1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping