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IL6 Break Apart FISH Probe

Empire Genomics’ IL6 Break Apart FISH Probe is designed to flank the IL6 gene and is typically used for detecting IL6 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
IL6BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
IL6BA-20-AQOR 20 (40 μL) 200 μL
IL6BA-20-GOGR 20 (40 μL) 200 μL
IL6BA-20-GORE 20 (40 μL) 200 μL
IL6BA-20-GRGO 20 (40 μL) 200 μL
IL6BA-20-GROR 20 (40 μL) 200 μL
IL6BA-20-GRRE 20 (40 μL) 200 μL
IL6BA-20-REGO 20 (40 μL) 200 μL
IL6BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Gene Details

Gene Symbol: IL6

Gene Name: Interleukin 6

Chromosome: CHR7: 22766765-22771621

Locus: 7p15.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct IL-1-alpha responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

This study investigated the effects of enhancers on chromatin remodeling and their cognate promoters during inflammation response. Of particular interest were two cytokine-induced factors on chromosome 4, IL-8 and IL-6. IL-8 controls secretion IL-8 and IL-6 factors, while also supporting sustained IL-1-alpha signaling to NF-kB and JNK/p38 MAP kinases. Our IL-8 and IL-6 probes, along with our chromosome 4 centromeric control probes, were used to detect extra copies of both genes in a tumor cell line.
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Product Details

Product: IL6 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: IL6-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping