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IL6 FISH Probe

The IL6 FISH probe is designed to hybridize to the IL6 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
IL6-20-OR  (Standard Design) 20 (40 μL) 200 μL
IL6-20-RE 20 (40 μL) 200 μL
IL6-20-GO 20 (40 μL) 200 μL
IL6-20-GR 20 (40 μL) 200 μL
IL6-20-AQ 20 (40 μL) 200 μL
IL6-20-DIG 20 (40 μL) 200 μL
IL6-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Gene Details

Gene Symbol: IL6

Gene Name: Interleukin 6

Chromosome: CHR7: 22766765-22771621

Locus: 7p15.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct IL-1-alpha responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

This study investigated the effects of enhancers on chromatin remodeling and their cognate promoters during inflammation response. Of particular interest were two cytokine-induced factors on chromosome 4, IL-8 and IL-6. IL-8 controls secretion IL-8 and IL-6 factors, while also supporting sustained IL-1-alpha signaling to NF-kB and JNK/p38 MAP kinases. Our IL-8 and IL-6 probes, along with our chromosome 4 centromeric control probes, were used to detect extra copies of both genes in a tumor cell line.
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Product Details

Product: IL6 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: IL6-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping