IL-12R FISH Probe
The IL-12R FISH probe is designed to hybridize to the IL-12R gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL12RB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-RE | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-GO | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-GR | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-AQ | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-DIG | 20 (40 μL) | 200 μL |  |
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| IL12RB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Details
Gene Symbol: IL12RB1
Gene Name: Interleukin 12 Receptor Subunit Beta 1
Chromosome: CHR19: 18170370-18197697
Locus: 19p13.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IL-12R FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IL12RB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping