IKAROS FISH Probe
The IKAROS FISH probe is designed to hybridize to the IKAROS gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IKZF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IKZF1-20-RE | 20 (40 μL) | 200 μL |  |
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| IKZF1-20-GO | 20 (40 μL) | 200 μL |  |
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| IKZF1-20-GR | 20 (40 μL) | 200 μL |  |
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| IKZF1-20-AQ | 20 (40 μL) | 200 μL |  |
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| IKZF1-20-DIG | 20 (40 μL) | 200 μL |  |
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| IKZF1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: IKZF1
Gene Name: IKAROS Family Zinc Finger 1
Chromosome: CHR7: 50344377-50472798
Locus: 7p12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IKAROS FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IKZF1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping