IGL Break Apart FISH Probe
Empire Genomics’ IGL Break Apart FISH Probe is designed to flank the IGL gene and is typically used for detecting IGL rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IGLBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| IGLBA-20-AQOR | 20 (40 μL) | 200 μL |
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| IGLBA-20-GOGR | 20 (40 μL) | 200 μL |
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| IGLBA-20-GORE | 20 (40 μL) | 200 μL |
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| IGLBA-20-GRGO | 20 (40 μL) | 200 μL |
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| IGLBA-20-GRRE | 20 (40 μL) | 200 μL |
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| IGLBA-20-ORGR | 20 (40 μL) | 200 μL |
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| IGLBA-20-REGO | 20 (40 μL) | 200 μL |
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| IGLBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: IGL
Gene Name: Immunoglobulin Lambda Locus
Chromosome: CHR22: 22026075-22922912
Locus: 22q11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IGL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IGL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping