IGKJ FISH Probe
The IGKJ FISH probe is designed to hybridize to the IGKJ gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IGKJ-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IGKJ-20-RE | 20 (40 μL) | 200 μL |  |
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| IGKJ-20-GO | 20 (40 μL) | 200 μL |  |
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| IGKJ-20-GR | 20 (40 μL) | 200 μL |  |
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| IGKJ-20-AQ | 20 (40 μL) | 200 μL |  |
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| IGKJ-20-DIG | 20 (40 μL) | 200 μL |  |
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| IGKJ-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa or lambda (see MIM 147220), joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig kappa light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGKC; MIM 147200), that provides signaling functions. The kappa light chain V region is encoded by 2 types of genes: V genes (see MIM 146980) and joining (J) genes. Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The kappa light chain locus on chromosome 2 contains approximately 40 functional V genes, followed by approximately 5 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]
Gene Details
Gene Symbol: IGKJ
Gene Name: Immunoglobulin Kappa Joining Cluster
Locus: 2p12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IGKJ FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IGKJ-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping