I1R FISH Probe
The I1R FISH probe is designed to hybridize to the I1R gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NISCH-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NISCH-20-RE | 20 (40 μL) | 200 μL |  |
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| NISCH-20-GO | 20 (40 μL) | 200 μL |  |
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| NISCH-20-GR | 20 (40 μL) | 200 μL |  |
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| NISCH-20-AQ | 20 (40 μL) | 200 μL |  |
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| NISCH-20-DIG | 20 (40 μL) | 200 μL |  |
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| NISCH-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Gene Details
Gene Symbol: NISCH
Gene Name: Nischarin
Chromosome: CHR3: 52489523-52527088
Locus: 3p21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: I1R FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NISCH-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping