HYOU1 FISH Probe
The HYOU1 FISH probe is designed to hybridize to the HYOU1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HYOU1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HYOU1-20-RE | 20 (40 μL) | 200 μL |  |
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| HYOU1-20-GO | 20 (40 μL) | 200 μL |  |
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| HYOU1-20-GR | 20 (40 μL) | 200 μL |  |
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| HYOU1-20-AQ | 20 (40 μL) | 200 μL |  |
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| HYOU1-20-DIG | 20 (40 μL) | 200 μL |  |
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| HYOU1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Details
Gene Symbol: HYOU1
Gene Name: Hypoxia Up-regulated 1
Chromosome: CHR11: 118914895-118927925
Locus: 11q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HYOU1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HYOU1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping