HST422 FISH Probe
The HST422 FISH probe is designed to hybridize to the HST422 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TYMS-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TYMS-20-RE | 20 (40 μL) | 200 μL |  |
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| TYMS-20-GO | 20 (40 μL) | 200 μL |  |
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| TYMS-20-GR | 20 (40 μL) | 200 μL |  |
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| TYMS-20-AQ | 20 (40 μL) | 200 μL |  |
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| TYMS-20-DIG | 20 (40 μL) | 200 μL |  |
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| TYMS-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: TYMS
Gene Name: Thymidylate Synthetase
Chromosome: CHR18: 657603-673499
Locus: 18p11.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HST422 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TYMS-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping