HSPBP1 FISH Probe
The HSPBP1 FISH probe is designed to hybridize to the HSPBP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HSBP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HSBP1-20-RE | 20 (40 μL) | 200 μL |  |
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| HSBP1-20-GO | 20 (40 μL) | 200 μL |  |
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| HSBP1-20-GR | 20 (40 μL) | 200 μL |  |
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| HSBP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| HSBP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| HSBP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HSBP1
Gene Name: Heat Shock Factor Binding Protein 1
Chromosome: CHR16: 83841592-83846594
Locus: 16q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HSPBP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HSBP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping