HSORC1 FISH Probe
The HSORC1 FISH probe is designed to hybridize to the HSORC1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ORC1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ORC1-20-RE | 20 (40 μL) | 200 μL |  |
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| ORC1-20-GO | 20 (40 μL) | 200 μL |  |
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| ORC1-20-GR | 20 (40 μL) | 200 μL |  |
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| ORC1-20-AQ | 20 (40 μL) | 200 μL |  |
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| ORC1-20-DIG | 20 (40 μL) | 200 μL |  |
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| ORC1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Details
Gene Symbol: ORC1
Gene Name: Origin Recognition Complex Subunit 1
Chromosome: CHR1: 52838500-52870143
Locus: 1p32.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HSORC1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ORC1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping