HSD17B1 FISH Probe
The HSD17B1 FISH probe is designed to hybridize to the HSD17B1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HSD17B1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HSD17B1-20-RE | 20 (40 μL) | 200 μL |  |
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| HSD17B1-20-GO | 20 (40 μL) | 200 μL |  |
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| HSD17B1-20-GR | 20 (40 μL) | 200 μL |  |
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| HSD17B1-20-AQ | 20 (40 μL) | 200 μL |  |
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| HSD17B1-20-DIG | 20 (40 μL) | 200 μL |  |
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| HSD17B1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Details
Gene Symbol: HSD17B1
Gene Name: Hydroxysteroid 17-beta Dehydrogenase 1
Chromosome: CHR17: 40703983-40707232
Locus: 17q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HSD17B1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HSD17B1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping