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HSD11B2 FISH Probe

The HSD11B2 FISH probe is designed to hybridize to the HSD11B2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HSD11B2-20-OR  (Standard Design) 20 (40 μL) 200 μL
HSD11B2-20-RE 20 (40 μL) 200 μL
HSD11B2-20-GO 20 (40 μL) 200 μL
HSD11B2-20-GR 20 (40 μL) 200 μL
HSD11B2-20-AQ 20 (40 μL) 200 μL
HSD11B2-20-DIG 20 (40 μL) 200 μL
HSD11B2-20-BIO 20 (40 μL) 200 μL

Gene Summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

Gene Details

Gene Symbol: HSD11B2

Gene Name: Hydroxysteroid 11-beta Dehydrogenase 2

Chromosome: CHR16: 67465035-67471454

Locus: 16q22.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: HSD11B2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: HSD11B2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping