HPTTG FISH Probe
The HPTTG FISH probe is designed to hybridize to the HPTTG gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTTG1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PTTG1-20-RE | 20 (40 μL) | 200 μL |  |
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| PTTG1-20-GO | 20 (40 μL) | 200 μL |  |
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| PTTG1-20-GR | 20 (40 μL) | 200 μL |  |
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| PTTG1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PTTG1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PTTG1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Details
Gene Symbol: PTTG1
Gene Name: Pituitary Tumor-transforming 1
Chromosome: CHR5: 159848864-159855746
Locus: 5q33.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HPTTG FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTTG1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping