HOGA1 Break Apart FISH Probe
Empire Genomics’ HOGA1 Break Apart FISH Probe is designed to flank the HOGA1 gene and is typically used for detecting HOGA1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HOGA1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-GORE | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-GROR | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-REGO | 20 (40 μL) | 200 μL |
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| HOGA1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Gene Details
Gene Symbol: HOGA1
Gene Name: 4-hydroxy-2-oxoglutarate Aldolase 1
Chromosome: CHR10: 99344101-99372555
Locus: 10q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HOGA1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HOGA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping