HNRNP-I FISH Probe
The HNRNP-I FISH probe is designed to hybridize to the HNRNP-I gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PTBP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PTBP1-20-RE | 20 (40 μL) | 200 μL |  |
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| PTBP1-20-GO | 20 (40 μL) | 200 μL |  |
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| PTBP1-20-GR | 20 (40 μL) | 200 μL |  |
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| PTBP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PTBP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PTBP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PTBP1
Gene Name: Polypyrimidine Tract Binding Protein 1
Chromosome: CHR19: 797391-812327
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HNRNP-I FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTBP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping