HNPCC4 FISH Probe
The HNPCC4 FISH probe is designed to hybridize to the HNPCC4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PMS2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PMS2-20-RE | 20 (40 μL) | 200 μL |  |
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| PMS2-20-GO | 20 (40 μL) | 200 μL |  |
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| PMS2-20-GR | 20 (40 μL) | 200 μL |  |
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| PMS2-20-AQ | 20 (40 μL) | 200 μL |  |
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| PMS2-20-DIG | 20 (40 μL) | 200 μL |  |
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| PMS2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: PMS2
Gene Name: PMS1 Homolog 2, Mismatch Repair System Component
Chromosome: CHR7: 6012869-6048737
Locus: 7p22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HNPCC4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PMS2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping