HMGCR FISH Probe
The HMGCR FISH probe is designed to hybridize to the HMGCR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HMGCR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HMGCR-20-RE | 20 (40 μL) | 200 μL |  |
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| HMGCR-20-GO | 20 (40 μL) | 200 μL |  |
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| HMGCR-20-GR | 20 (40 μL) | 200 μL |  |
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| HMGCR-20-AQ | 20 (40 μL) | 200 μL |  |
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| HMGCR-20-DIG | 20 (40 μL) | 200 μL |  |
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| HMGCR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Details
Gene Symbol: HMGCR
Gene Name: 3-hydroxy-3-methylglutaryl-CoA Reductase
Chromosome: CHR5: 74632992-74657926
Locus: 5q13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HMGCR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HMGCR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping