The HMGCR FISH probe is designed to hybridize to the HMGCR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HMGCR-20-OR  (Standard Design) 20 (40 μL) 200 μL
HMGCR-20-RE 20 (40 μL) 200 μL
HMGCR-20-GO 20 (40 μL) 200 μL
HMGCR-20-GR 20 (40 μL) 200 μL
HMGCR-20-AQ 20 (40 μL) 200 μL
HMGCR-20-DIG 20 (40 μL) 200 μL
HMGCR-20-BIO 20 (40 μL) 200 μL

Gene Summary

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Details

Gene Symbol: HMGCR

Gene Name: 3-hydroxy-3-methylglutaryl-CoA Reductase

Chromosome: CHR5: 74632992-74657926

Locus: 5q13.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: HMGCR FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL


Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping