HLE FISH Probe
The HLE FISH probe is designed to hybridize to the HLE gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ELANE-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ELANE-20-RE | 20 (40 μL) | 200 μL |  |
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| ELANE-20-GO | 20 (40 μL) | 200 μL |  |
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| ELANE-20-GR | 20 (40 μL) | 200 μL |  |
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| ELANE-20-AQ | 20 (40 μL) | 200 μL |  |
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| ELANE-20-DIG | 20 (40 μL) | 200 μL |  |
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| ELANE-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: ELANE
Gene Name: Elastase, Neutrophil Expressed
Chromosome: CHR19: 852290-856246
Locus: 19p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HLE FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ELANE-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping