HLA-DXB FISH Probe
The HLA-DXB FISH probe is designed to hybridize to the HLA-DXB gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-DQB2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HLA-DQB2-20-RE | 20 (40 μL) | 200 μL |  |
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| HLA-DQB2-20-GO | 20 (40 μL) | 200 μL |  |
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| HLA-DQB2-20-GR | 20 (40 μL) | 200 μL |  |
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| HLA-DQB2-20-AQ | 20 (40 μL) | 200 μL |  |
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| HLA-DQB2-20-DIG | 20 (40 μL) | 200 μL |  |
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| HLA-DQB2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]
Gene Details
Gene Symbol: HLA-DQB2
Gene Name: Major Histocompatibility Complex, Class II, DQ Beta 2
Chromosome: CHR6_qbl_hap6: 3955994-3963453
Locus: 6p21.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HLA-DXB FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-DQB2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping