HLA-DQB1 FISH Probe
The HLA-DQB1 FISH probe is designed to hybridize to the HLA-DQB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-DQB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HLA-DQB1-20-RE | 20 (40 μL) | 200 μL |  |
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| HLA-DQB1-20-GO | 20 (40 μL) | 200 μL |  |
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| HLA-DQB1-20-GR | 20 (40 μL) | 200 μL |  |
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| HLA-DQB1-20-AQ | 20 (40 μL) | 200 μL |  |
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| HLA-DQB1-20-DIG | 20 (40 μL) | 200 μL |  |
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| HLA-DQB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Details
Gene Symbol: HLA-DQB1
Gene Name: Major Histocompatibility Complex, Class II, DQ Beta 1
Chromosome: CHR6_cox_hap2: 4072510-4080111
Locus: 6p21.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HLA-DQB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-DQB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping