HLA-DOB Break Apart FISH Probe
Empire Genomics’ HLA-DOB Break Apart FISH Probe is designed to flank the HLA-DOB gene and is typically used for detecting HLA-DOB rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-DOBBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HLA-DOBBA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLA-DOB
Gene Name: Major Histocompatibility Complex, Class II, DO Beta
Chromosome: CHR6_ssto_hap7: 4211472-4215758
Locus: 6p21.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: HLA-DOB FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-DOB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping