HLA-A Break Apart FISH Probe
Empire Genomics’ HLA-A Break Apart FISH Probe is designed to flank the HLA-A gene and is typically used for detecting HLA-A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HLA-ABA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-AQOR | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-GOGR | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-GORE | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-GRGO | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-GROR | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-GRRE | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-REGO | 20 (40 μL) | 200 μL |
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| HLA-ABA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLA-A
Gene Name: Major Histocompatibility Complex, Class I, A
Chromosome: CHR6_mcf_hap5: 1150097-1295564
Locus: 6p22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HLA-A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping