HFE2 Break Apart FISH Probe
Empire Genomics’ HFE2 Break Apart FISH Probe is designed to flank the HFE2 gene and is typically used for detecting HFE2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HFE2BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| HFE2BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
Gene Details
Gene Symbol: HFE2
Gene Name: Hemochromatosis Type 2 (juvenile)
Chromosome: CHR1: 145413190-145417545
Locus: 1q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: HFE2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HFE2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping