HEL-S-268 FISH Probe
The HEL-S-268 FISH probe is designed to hybridize to the HEL-S-268 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SPAG1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SPAG1-20-RE | 20 (40 μL) | 200 μL |  |
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| SPAG1-20-GO | 20 (40 μL) | 200 μL |  |
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| SPAG1-20-GR | 20 (40 μL) | 200 μL |  |
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| SPAG1-20-AQ | 20 (40 μL) | 200 μL |  |
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| SPAG1-20-DIG | 20 (40 μL) | 200 μL |  |
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| SPAG1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: SPAG1
Gene Name: Sperm Associated Antigen 1
Chromosome: CHR8: 101170262-101254132
Locus: 8q22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HEL-S-268 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SPAG1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping