HDMX FISH Probe
The HDMX FISH probe is designed to hybridize to the HDMX gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MDM4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MDM4-20-RE | 20 (40 μL) | 200 μL |  |
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| MDM4-20-GO | 20 (40 μL) | 200 μL |  |
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| MDM4-20-GR | 20 (40 μL) | 200 μL |  |
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| MDM4-20-AQ | 20 (40 μL) | 200 μL |  |
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| MDM4-20-DIG | 20 (40 μL) | 200 μL |  |
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| MDM4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: MDM4
Gene Name: MDM4, P53 Regulator
Chromosome: CHR1: 204485506-204527248
Locus: 1q32.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HDMX FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MDM4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping